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Synfacts 2008(12): 1249-1249  
DOI: 10.1055/s-0028-1087286
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Meloscine

Contributor(s): Philip Kocienski, Zofia Komsta
P. Selig, T. Bach*
Technische Universität München, Garching, Germany
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

(+)-Meloscine is one of the alkaloids isolated from certain plants from Apocynacea species, used in Chinese folk medicine. The synthesis highlights construction of the cyclobutane ring in D via a regio- and stereoselective template-controlled [2+2] cycloaddition. The dr of the cycloaddition was not reported.