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Synfacts 2008(12): 1303-1303  
DOI: 10.1055/s-0028-1087320
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Air-Stable Iridium Catalyst in Asymmetric Allylic Substitution

Contributor(s): Mark Lautens, Jane Panteleev
S. Spiess, C. Welter, G. Franck, J.-P. Taquet, G. Helmchen*
Ruprecht-Karls-UniversitÄt Heidelberg, Germany
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Publikationsdatum:
20. November 2008 (online)

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Significance

The authors report a new iridium catalyst system for the asymmetric allylic substitution reaction, furnishing improved chemoselectivity and comparable yields without the need for ­inert atmosphere. Additional mechanistic insight into precatalyst formation is reported based on ³¹P NMR experiments.