Synthesis of 15G256β

I. Navarro; J.-F. Basset; S. Hebbe; S. M. Major; T. Werner; C. Howsham; J. Bräckow; A. G. M. Barrett

doi:10.1055/s-0028-1087599

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Synfacts 2009(2): 0124-0124
DOI: 10.1055/s-0028-1087599

Synthesis of Natural Products and Potential Drugs

Synthesis of 15G256β

Contributor(s): Philip Kocienski
I. Navarro, J.-F. Basset, S. Hebbe, S. M. Major, T. Werner, C. Howsham, J. Bräckow, A. G. M. Barrett*
Imperial College London, UK

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Publication History

Publication Date:
22 January 2009 (online)

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Significance

15G258β is an antifungal agent isolated from the marine fungus Hypoxylon oceanicum LL-15G256. A salient feature of the Barrett synthesis is the construction of the resorcinol derivative I by biomimetic cyclization of the tetraketide H.