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Synfacts 2009(5): 0476-0476  
DOI: 10.1055/s-0028-1088175
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ()-Lysergic Acid

Contributor(s): Philip Kocienski, Arndt W. Schmidt
S. Inuki, S. Oishi, N. Fujii*, H. Ohno*
Kyoto University, Japan
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Publication History

Publication Date:
22 April 2009 (online)

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Significance

Ergot alkaloids like lysergic acid and their synthetic derivatives exhibit a broad range of biological activities and have been used for the treatment of Alzheimer’s disease and in ­antiprolactin drugs. The focal step of this synthesis is the palladium-catalyzed cyclization of bromo­indolyl-substituted allene F to form the C/D ring system I in a single operation.