Antifungal Triterpene Glycosides from the Sea Cucumber Bohadschia marmorata

Abstract

Four new holostan-type triterpene glycosides, marmoratoside A (1), 17α-hydroxy impatienside A (2), marmoratoside B (3), 25-acetoxy bivittoside D (4), together with two known triterpene glycosides, impatienside A (5) and bivittoside D (6), were isolated from the sea cucumber Bohadschia marmorata Jaeger. On the basis of spectroscopic analyses, including two-dimensional NMR techniques, and chemical reactions, the structures of the new triterpene glycosides were elucidated. Compounds 1, 2, 5, and 6 exhibited significant antifungal activity against six strains (0.70 ≤ MIC₈₀ ≤ 2.81 μM).

sea cucumber - Bohadschia marmorata - triterpene glycoside - antifungal

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