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DOI: 10.1055/s-0029-1185698
© Georg Thieme Verlag KG Stuttgart · New York
Sesquiterpene Lactone 12,8-Eudesmanolides from the Fungus Xylaria ianthinovelutina
Publication History
received February 3, 2009
revised March 24, 2009
accepted April 2, 2009
Publication Date:
18 May 2009 (online)
Abstract
The investigation of Xylaria ianthinovelutina (Mont.) led to the isolation of four new 12,8-eudesmanolides (1–4). Their structures were determined by spectroscopy and the relative stereochemistry was assigned based on NOESY and CD spectral data. Compounds 1–4 exhibited biological activity against Plasmodium falciparum K-1 strain, NCI-H187, KB, MCF-7 with IC50 values varying in the range 0.78–19.15 µg/mL.
Key words
Xylariaceae - Xylaria - Xylaria ianthinovelutina - sesquiterpene lactones - 12,8‐eudesmanolides
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