Planta Med 2009; 75(13): 1431-1435
DOI: 10.1055/s-0029-1185698
Natural Product Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Sesquiterpene Lactone 12,8-Eudesmanolides from the Fungus Xylaria ianthinovelutina

Pattama Pittayakhajonwut1 , Atit Usuwan1 , Chakapong Intaraudom1 , Sukitaya Veeranondha1 , Prasert Srikitikulchai1
  • 1National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani, Thailand
Further Information

Publication History

received February 3, 2009 revised March 24, 2009

accepted April 2, 2009

Publication Date:
18 May 2009 (online)

Abstract

The investigation of Xylaria ianthinovelutina (Mont.) led to the isolation of four new 12,8-eudesmanolides (14). Their structures were determined by spectroscopy and the relative stereochemistry was assigned based on NOESY and CD spectral data. Compounds 14 exhibited biological activity against Plasmodium falciparum K-1 strain, NCI-H187, KB, MCF-7 with IC50 values varying in the range 0.78–19.15 µg/mL.

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Dr. Pattama Pittayakhajonwut

National Center for Genetic Engineering and Biotechnology (BIOTEC)
Thailand Science Park

Paholyothin Road

Klong Luang

12120 Pathumthani

Thailand

Phone: + 66 25 64 67 00 ext. 35 59

Fax: + 66 25 64 66 32

Email: pattamap@biotec.or.th

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