Eur J Pediatr Surg 2009; 19(4): 216-219
DOI: 10.1055/s-0029-1202282
Original Article

© Georg Thieme Verlag KG Stuttgart · New York

Hydrocephalus in Infants Less than Six Months of Age: Effectiveness of Endoscopic Third Ventriculostomy

R. Faggin1 , A. Bernardo2 , P. Stieg2 , G. Perilongo1 , D. d’Avella1
  • 1Department of Pediatric Neurosurgery, University of Padua, Padua, Italy
  • 2Department of Neurological Surgery, NYC, Weill Medical College of Cornell University, New York, United States
Further Information

Publication History

received August 6, 2008

accepted after revision January 6, 2009

Publication Date:
03 April 2009 (online)

Abstract

Objective: Although endoscopic third ventriculostomy (ETV) is a well established procedure for the treatment of congenital and acquired hydrocephalus, there is still a controversy with regard to the higher risk of failure in younger infants compared to older children after such a procedure. The aim of this article is to define the effectiveness of third ventriculostomy for hydrocephalus in infants less than 6 months of age better and to determine possible positive predictive factors.

Materials and Methods:In a series of 126 consecutive patients who underwent ETV between January 2000 and December 2002, 21 procedures were performed on infants ranging in age from 23 to 180 days, and without a previous history of shunting. The follow-up period was 49 to 82 months.

Results: The overall success rate of ETV was 67% (14/21). All failures occurred in the early postoperative period (average 38 days, range 25–88 days). The success rate varied with the etiology of the patient's hydrocephalus. The best results were obtained in patients with acqueductal stenosis, Dandy-Walker malformation and myelomeningocele. The least favorable results (50% failure rate) occurred in infants treated for post-hemorrhagic and post-meningitic hydrocephalus.

Conclusion: This study does not demonstrate a correlation between the age of the infants and the ETV success rate. The specific etiology of hydrocephalus is the most relevant prognostic factor in infants under six months of age.

References

  • 1 Alvarez JA, Cohen AR. Neonatal applications of neuroendoscopy.  Neurosurg Clin N Am. 1998;  9 405-413
  • 2 Balthasar A, Kort H, Comips EM, Beuls E, Weber JW, Vles JS. Analysis of the success and failure of endoscopic third ventriculostomy in infants less than 1 year of age.  Child's Nerv Syst. 2006;  22 1548-1553
  • 3 Beems T, Grotenhuis JA. Endoscopic third ventriculostomy – is its success rate age-dependent?. , Third International Hydrocephalus Workshop Kos, Greece, May 17–20, 2001 (Abstract)
  • 4 Buxton N, Macarthur D, Mallucci C, Punt J, Vloeberghs M. Neuroendoscopic third ventriculostomy in patients less than 1 year old.  Pediatr Neurosurg. 1998;  29 73-76
  • 5 Buxton N, Macarthur D, Mallucci C, Punt J, Vloeberghs M. Neuroendoscopy in the premature population.  Childs Nerv Syst. 1998;  14 649-652
  • 6 Cinalli G, Sainte-Rose C, Chumas P, Zerah M, Brunelle F, Lot G, Pierre-Khan A, Renier D. Failure of third ventriculostomy in the treatment of aqueductal stenosis in children.  J Neurosurg. 1999;  90 448-454
  • 7 Cohen AR. Endoscopic ventricular surgery.  Pediatr Neurosurg. 1994;  19 127-134
  • 8 Di Rocco C, Massimi L, Tamburrini G. Shunt vs endoscopic third ventriculostomy in infants: are there different types and/or rates of complications?.  Child's Nerv Syst. 2006;  22 1573-1589
  • 9 Fritsch MJ, Kienke S, Ankermann T, Padoin M, Mehdorn M. Endoscopic third venticulostomy in infants.  J Neurosurg (Pediatrics 1). 2005;  103 50-53
  • 10 Gorayer R, Cavalheiro S, Zymberg T. Endoscopic third ventriculostomy in children younger than 1 year of age.  J Neurosurg (Pediatrics 5). 2004;  100 427-429
  • 11 Grotenhuis JA, Beems T. The role of endoscopic third ventriculostomy in the treatment of hydrocephalus associated with myelomeningocele.  Minim Invasive Neurosurg. 1999;  42 161-162
  • 12 Hirsch JF. Percutaneous ventriculo cisternostomies in non communicating hydrocephalus.  Monogr Neurol Sci. 1982;  8 170-178
  • 13 Javadpour M, May P, Mallucci C. Sudden death secondary to delayed closure of endoscopic third ventriculostomy.  Br J Neurosurg. 2003;  17 266-269
  • 14 Jones RFC, Stening WA, Brydon M. Endoscopic third ventriculostomy.  Neurosurgery. 1990;  26 86-92
  • 15 Koch D, Wagner W. Endoscopic third ventriculostomy in infants of less 1 year of age: which factors influence the outcome?.  Child's Nerv Syst. 2004;  20 405-411
  • 16 Koch D, Wagner W. Success and failure of endoscopic third ventriculostomy in young infants: are there different age distributions?.  Child's Nerv Syst. 2006;  22 1555-1567
  • 17 Kunz U, Goldman A, Bader C, Waldbauer H, Oldenkott P. Endoscopic fenestration of the 3rd ventricular floor in aqueductal stenosis.  Minim Invasive Neurosurg. 1994;  37 42-47
  • 18 Mobbs R, Vonau M, Davies M. Death after late failure of endoscopic third ventriculostomy; a potential solution.  Neurosurgery. 2003;  53 384-389
  • 19 Mohanty A, Vasudev MK, Sampath S, Radhesh S, Sastry Kolluri VR. Failed endoscopic third ventriculostomy in children: management options.  Pediatr Neurosurg. 2002;  37 304-309
  • 20 O’ Brien DF, Seghedoni A, Collins DR, Hayhurst C, Mallucci CL. Is there an indication for ETV in young infants in aetiologies other than isolated aqueduct stenosis?.  Child's Nerv Syst. 2006;  22 1565-1572
  • 21 Oi S, Di Rocco C. Proposal of “evolution theory in cerebrospinal fluid dynamics” and minor pathway hydrocephalus in developing immature brain.  Child's Nerv Syst. 2006;  22 662-668
  • 22 Rekate HL. Selecting patients for endoscopic third ventriculostomy.  Neurosurg Clin N Am. 2004;  15 39-49
  • 23 Sainte-Rose C, Chumas P. Endoscopic third ventriculostomy.  Tech Neurosurg. 1996;  1 176-184
  • 24 Schroeder HW, Niendorf WR, Gaab MR. Complications of endoscopic third ventriculostomy.  J Neurosurg. 2002;  96 1031-1040
  • 25 Siomin V, Weiner H, Wisoff J, Cinalli G, Pierre Khan A, Sainte-Rose C, Abbott R, Elran H, Beni-Adani L, Ouaknine G, Constantini S. Repeat endoscopic third ventriculostomy: is it worth trying?.  Child's Nerv Syst. 2001;  17 551-555
  • 26 Siomin V, Cinalli G, Grotenhuis A, Golash A, Oi S, Kothbauer K, Einer H, Roth J, Beni Adani L, Pierre Kahn A, Takahashi Y, Malucci C, Abbott R. Wisoff. Endoscopic third ventriculostomy in patients with cerebrospinal fluid infection and/or hemorrhage.  J Neurosurg. 2002;  97 519-524
  • 27 Tuli S, Drake J, Lawless J, Wig M. Risk factors for repeated cerebrospinal shunt failures in pediatric patients with hydrocephalus.  J Neurosurg. 2000;  92 31-38
  • 28 Wagner W, Koch D. Mechanisms of failure after endoscopic third ventriculostomy in young infants.  J Neurosurg (Pediatrics 1). 2005;  103 43-49

Correspondence

Dr. R. FagginMD 

Department of Pediatric Neurosurgery

University of Padua

via Giustiniani n 2

35128 Padova

Italy

Phone: +39/049 821 80 36

Fax: +39/049/821 17 81

Email: rfaggin@yahoo.it

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