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Synthesis 2009(13): 2143-2145
DOI: 10.1055/s-0029-1216817
DOI: 10.1055/s-0029-1216817
SHORTPAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkA Novel and Convenient Synthesis of ‘Reversed’ Diamidino 2,5-Aryl- and 2,5-Azaheterocycle-Substituted Furans
Further Information
Received
12 January 2009
Publication Date:
14 May 2009 (online)
Publication History
Publication Date:
14 May 2009 (online)
Abstract
A novel and convenient two-step synthesis of ‘reversed’ diamidino 2,5-aryl- and 2,5-azaheterocycle-substituted furans is described. The key step, a Stille cross-coupling reaction between N-(bromoaryl)arenecarboxamidines and 2,5-bis(tri-n-butylstannyl)furan, is reported for the first time.
Key words
reversed amidines - thioimidates - Stille cross-coupling reaction - furans - N-heterocycles
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