Palladium-Catalyzed One-Pot
Synthesis of 4-Aryl-1H-1,2,3-triazoles
from anti-3-Aryl-2,3-dibromopropanoic
Acids and Sodium Azide

Wensheng Zhang; Chunxiang Kuang; Qing Yang

doi:10.1055/s-0029-1217097

PAPER

Palladium-Catalyzed One-Pot Synthesis of 4-Aryl-1H-1,2,3-triazoles from anti-3-Aryl-2,3-dibromopropanoic Acids and Sodium Azide

Wensheng Zhang^a,b, Chunxiang Kuang*^a, Qing Yang^c
^a Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China
Fax: +86(21)65983191; e-Mail: kuangcx@tongji.edu.cn;
^b Department of Chemistry, Jiaozuo Teachers’ College, Jiaozuo 454001, P. R. of China
^c Department of Biochemistry, School of Life Sciences, Fudan University, Handan Road 220, Shanghai 200433, P. R. of China

Abstract

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Abstract

4-Aryl-1H-1,2,3-triazoles were synthesized from anti-3-aryl-2,3-dibromopropanoic acids and sodium azide by a one-pot method using N,N-dimethylformamide as solvent in the presence of tris(dibenzylideneacetone)dipalladium(0) [Pd₂(dba)₃] and Xantphos.

Key words

1H-1,2,3-triazole - anti-3-aryl-2,3-dibromopropanoic acid - sodium azide - Pd₂(dba)₃ - one-pot

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References

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