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Synfacts 2009(11): 1185-1185  
DOI: 10.1055/s-0029-1218033
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Oseltamivir

Contributor(s): Philip Kocienski
B. Sullivan, I. Carrera, M. Drouin, T. Hudlicky*
Brock University, St. Catharines, Canada and Universidad de la República, Montevideo, Uruguay
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Publication History

Publication Date:
22 October 2009 (online)

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Significance

Oseltamvir (Tamiflu) is the prime drug for the treatment of avian H1N1 influenza. Syntheses of oseltamivir starting with enzymatic dihydroxylation of bromobenzene were reported in 2008 by the groups of Hudlicky, Fang, and Banwell. By starting with ethyl benzoate, the synthesis depicted avoids a palladium-catalyzed carbonylation to install the ester function.