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Synfacts 2010(1): 0011-0011  
DOI: 10.1055/s-0029-1218261
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

CXCR4 Antagonist (GSK812397)

Contributor(s): Philip Kocienski
S. Boggs, V. I. Elitzin*, K. Gudmundsson, M. T. Martin, M. J. Sharp
GlaxoSmithKline, Research Triangle Park, USA
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Publikationsdatum:
21. Dezember 2009 (online)

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Significance

CXC chemokine receptor 4 (CXCR4) is a transmembrane protein that is a host co-receptor for a number of HIV-1 strains. CXCR-4 antagonists could be beneficial in suppressing the replication of late-stage viruses. GSK812397 is a lead for the treatment of HIV infection.