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Synfacts 2010(1): 0015-0015  
DOI: 10.1055/s-0029-1218264
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Gymnodimine

Contributor(s): Philip Kocienski
K. Kong, D. Romo*, C. Lee
Texas A&M University, College Station, USA
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Publication History

Publication Date:
21 December 2009 (online)

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Significance

Key steps in the synthesis of the marine neurotoxin gymnodimine were (1) a ­Nozaki-Hiyama-Kishi reaction linking A and B; (2) the Barbier-type macrocyclization reaction (D → E); and (3) the Mukaiyama aldol reaction linking F and G.