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Synfacts 2010(1): 0020-0020  
DOI: 10.1055/s-0029-1218396
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of (±)-Platencin

Contributor(s): Philip Kocienski, Stewart Eccles
A. K. Ghosh*, K. Xi
Purdue University, West Lafayette, USA
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Publication History

Publication Date:
21 December 2009 (online)

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Significance

Platencin was isolated from Streptomyces platensis along with platencimycin. Both molecules have generated a great deal of interest owing to their potent antibacterial activity against drug-resistant strains. The activity is attributed to the novel and dual mode of action. The paper reports a concise route to the platencin core.