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Synfacts 2010(1): 0094-0094  
DOI: 10.1055/s-0029-1218433
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Olefin Cyclopropanation by Sequential Radical Addition/Dechlorination

Contributor(s): Paul Knochel, Andreas J. Wagner
K. Thommes, G. Kiefer, R. Scopelliti, K. Severin*
École Polytechnique Fédérale de Lausanne, Switzerland
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Publikationsdatum:
21. Dezember 2009 (online)

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Significance

Magnesium is shown to react with di- or trichloroalkanes in the presence of (Ph3P)Ru(Cp*)Cl2 and an alkene, giving rise to substituted cyclopropanes. This one-pot conversion is a sequence of ATRA (atom-transfer radical addition) and dechlorination reactions.