Olefin Cyclopropanation by Sequential Radical Addition/Dechlorination

K. Thommes; G. Kiefer; R. Scopelliti; K. Severin

doi:10.1055/s-0029-1218433

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Synfacts 2010(1): 0094-0094
DOI: 10.1055/s-0029-1218433

Metal-Mediated Synthesis

Olefin Cyclopropanation by Sequential Radical Addition/Dechlorination

Contributor(s): Paul Knochel, Andreas J. Wagner
K. Thommes, G. Kiefer, R. Scopelliti, K. Severin*
École Polytechnique Fédérale de Lausanne, Switzerland

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Publication History

Publication Date:
21 December 2009 (online)

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Significance

Magnesium is shown to react with di- or trichloroalkanes in the presence of (Ph₃P)Ru(Cp*)Cl₂ and an alkene, giving rise to substituted cyclopropanes. This one-pot conversion is a sequence of ATRA (atom-transfer radical addition) and dechlorination reactions.