Download PDF
Synfacts 2010(1): 0074-0074  
DOI: 10.1055/s-0029-1218479
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Aluminum-Catalyzed Asymmetric Strecker Reaction

Contributor(s): Mark Lautens, Jane Panteleev
J. P. Abell, H. Yamamoto*
The University of Chicago, USA
Further Information

Publication History

Publication Date:
21 December 2009 (online)

    Permissions and Reprints

Significance

The authors report an application of their chiral aluminum catalyst in the Strecker reaction. This transformation has been extensively examined in terms of asymmetric induction (see ­Review below). The authors contribute to the field by ­applying a more benign cyanide source and by demonstrating an efficient catalytic system capable of asymmetric addition to both aldimines and ketimines.

Review: H. Gröger Chem. Rev. 2003, 103, 2795-2827.