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Synthesis 2010(11): 1766-1770
DOI: 10.1055/s-0029-1218732
DOI: 10.1055/s-0029-1218732
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkTotal Synthesis of (-)-Δ8-trans-Tetrahydrocannabinol
Further Information
Received
21 January 2010
Publication Date:
12 April 2010 (online)
Publication History
Publication Date:
12 April 2010 (online)
Abstract
(-)-Δ8-trans-Tetrahydrocannabinol was synthesized with high regio- and stereoselectivity through SN2′ addition of an arylcyanocuprate to the optically pure enol silyl ether of α,β-epoxycyclohexanone.
Key words
addition reactions - heterocycles - tetrahydrocannabinol - deoxygenation - stereoselective synthesis
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