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Synthesis 2010(7): 1181-1187
DOI: 10.1055/s-0029-1219224
DOI: 10.1055/s-0029-1219224
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkTotal Synthesis of Ailanthoidol, Egonol, and Related Analogues
Further Information
Received
26 November 2009
Publication Date:
12 January 2010 (online)
Publication History
Publication Date:
12 January 2010 (online)
Abstract
Efficient and general synthetic protocols were developed for the total synthesis of ailanthoidol, egonol, and some related analogues. The key transformations describe here involve a two-step construction of the benzofuran and a Sonogashira coupling, and proved to be convenient and effective, starting from readily available reagents.
Key words
benzofurans - cross-coupling - McMurry reaction - Sonogashira coupling - natural products
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