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Synfacts 2010(4): 0471-0471  
DOI: 10.1055/s-0029-1219520
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

A Biocatalytic Equivalent to the Nef Reaction

Contributor(s): Benjamin List, Kristina Zumbansen
K. Durchschein, B. Ferreira-da Silva, S. Wallner, P. Macheroux, W. Kroutil, S. M. Glueck, K. Faber
Universität Graz and Technische Universität Graz, Austria
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Publication History

Publication Date:
22 March 2010 (online)

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Significance

Faber and co-workers report a bioreduction of aliphatic secondary nitro compounds catalyzed by purified flavoproteins from the old yellow enzyme family providing the corresponding carbonyl compounds. NADH, NADPH, or the oxidized forms NAD+ and NAD(P)+ were used in combination with a recycling enzyme as cofactor. Primary nitroalkanes and short chain secondary analogues were not converted under the described conditions.