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Synfacts 2010(4): 0460-0460  
DOI: 10.1055/s-0029-1219599
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

1,3-Diketone Synthesis via a Novel Tandem Reaction

Contributor(s): Paul Knochel, Tobias Thaler
M. Sada, S. Matsubara*
Kyoto University, Japan
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Publikationsdatum:
22. März 2010 (online)

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Significance

A novel tandem approach to the synthesis of 1,3-diketones has been disclosed. This reaction combines three reaction steps and proceeds via 1,4-addition of bis(iodozincio)methane to the enone followed by intramolecular acylation and Grob-type fragmentation.