Triterpene Saponins from Cyclamen trocopteranthum

Abstract

Two new triterpene saponins (1–2) together with three known saponins, deglucocyclamin I (3), cyclamin (4), and mirabilin (5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3β-O-{4-O-[3-hydroxyl-3-methylglutaryl]-β-D-xylopyranosyl-(1 → 2)-β-D-glucopyranosyl-(1 → 4)-[β-D-glucopyranosyl-(1 → 2)]-α-L-arabinopyranosyl}-16α-hydroxy-13β,28-epoxy-oleanan-30-al (1) and 3β-O-{4-O-[3-hydroxyl-3-methylglutaryl]-β-D-xylopyranosyl-(1 → 2)-[β-D-glucopyranosyl-(1 → 6)]-β-D-glucopyranosyl-(1 → 4)-[β-D-glucopyranosyl-(1 → 2)]-α-L-arabinopyranosyl}-16α-hydroxy-20,30-lactone-olean-12-ene (2). Their structures were characterized mainly by a combination of 1D- and 2D‐NMR techniques (¹H-¹H COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectroscopy. Saponins 1, 3, and 4 showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells.

Key words

Cyclamen trocopteranthum - Primulaceae - triterpene saponin - dicrotalic acid

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