Download PDF
Planta Med 2000; 66(2): 182-184
DOI: 10.1055/s-0029-1243128
Letter

© Georg Thieme Verlag Stuttgart · New York

5-(4-Hydroxyphenethenyl)-4,7-dimethoxycoumarin, a New Constituent of Monotes engleri

Eun-Kyoung Seo1 , 3 , Hee-Byung Chai1 , Tangai E. Chagwedera2 , Norman R. Farnsworth1 , Geoffrey A. Cordell1 , John M. Pezzuto1 , A. Douglas Kinghorn1 ,*
  • 1Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, U.S.A.
  • 2Department of Pharmacy, University of Zimbabwe, Harare, Zimbabwe
  • 3Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina, U.S.A.
Further Information

Publication History

Received: March 23, 1999

Accepted: June 26, 1999

Publication Date:
26 November 2009 (online)

    Permissions and Reprints

Abstract

A new coumarin, 5-(4-hydroxyphenethenyl)-4,7-dimethoxycoumarin (1) was isolated from the combined ethyl acetate extracts of the root bark, root wood and stem bark of Monotes engleri, and found to be cytotoxic against two cell lines in a human tumor panel. Its structure was determined on the basis of spectroscopic methods.

References

  • 1 Seo E -K, Silva G L, Chai H -B, Chagwedera T E, Farnsworth N R, Cordell G A, Pezzuto J M, Kinghorn A D. Phytochemistry 1997 45: 509-515
    PubMed
  • 2 Silverstein R M, Bassler G C, Morrill T C. Spectroscopic Identification of Organic Compounds Fifth Edition. New York; John Wiley & Sons 1991: pp. 91-164
    PubMedGoogle Scholar
  • 3 Vilegas W, Pozetti G L, Vilegas J HY. J. Nat. Prod 1993 56: 416-417
    PubMed
  • 4 Abaul J, Philogéne É, Bourgeois P, Poupat C, Ahond A, Potier P. J Nat Prod 1994 57: 846-848
    PubMed
  • 5 Debenedetti S L, Palacios P S, Nadinic E L, Coussio J D, de Kimpe N, Boeykens M, Feneau-Dupont J, Declercq J -P. J Nat Prod 1994 57: 1539-1542
    PubMed
  • 6 Laakso J A, Narske E D, Gloer J B, Wicklow D T, Dowd P F. 1994 57: 128-133
    PubMed
  • 7 Bax A. J Magn Res 1984 57: 314-318
    PubMed
  • 8 Likhitwitayawuid K, Angerhofer C K, Cordell G A, Pezzuto J M, Ruangrungsi N. J Nat Prod 1993 56: 30-38
    PubMed

Prof. A. Douglas Kinghorn, Ph.D., D.Sc.

Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy

College of Pharmacy

University of Illinois at Chicago

833 South Wood Street (M/C 781)

Chicago, IL 60612

U.S.A.

Email: Kinghorn@uic.edu

Fax: +1-312-996-7107

Phone: +1-312-996-0914

      >