Abstract
Two new tetrahydroprotoberberine-aporphine dimeric alkaloids, corydaturtschines A
(1) and B (2), and a new aporphine derivative, ethyl glausuccinate (3), together with 13 known protoberberine (4–16) and nine known aporphine alkaloids (17–25), were isolated from the tubers of Corydalis turtschaninovii. The structures of these new compounds were determined through spectral analyses,
including extensive 2D‐NMR data. The absolute configurations of the compounds were
clarified by CD spectroscopic studies. The isolated compounds were tested for their
cytotoxicity against four human cancer cell lines in vitro using a sulforhodamine B bioassay.
Key words
Corydalis turtschaninovii
- Papaveraceae - tetrahydroprotoberberine‐aporphine dimmer - aporphine - cytotoxicity
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Prof. Dr. Kang Ro Lee
Natural Products Laboratory
School of Pharmacy
Sungkyunkwan University
300 Chunchun-dong
Jangan-ku, Suwon 440–746
Korea
Phone: + 82 3 12 90 77 10
Fax: + 82 3 12 90 77 30
Email: krlee@skku.ac.kr
