Immunosuppressive Sesquiterpenes from Buddleja daviddi

Abstract

Six new sesquiterpenes, 2,6(12),10-humulatrien-7β-ol-1-one (1), 2α-acetoxy-5α-methoxy-enantio-caryophylla-8(15)-en-3-one (2), 2α-acetoxy-5α-hydroxy-enantio-caryophylla-8(15)-en-3-one (3), 2α-acetoxy-4β,5α-hydroxy-enantio-caryophylla-8(15)-en-3-one (4), 2α-acetoxy-4β,5β-hydroxy-enantio-caryophylla-8(15)-en-3-one (5), 2β-acetoxy-4-caryophyllen-8β-ol-3-one (6), and nineteen known compounds were isolated from the ethanol extract of Buddleja daviddi. The structures were elucidated by spectroscopic methods. Compounds 8–11, 14, 16, 17, and 20 showed significant immunosuppressive activities, and 8–11 and 14 were cytotoxic on HeLa and L929 cell lines.

Buddleja daviddi - Loganiaceae - humulane sesquiterpene - caryophyllane sesquiterpene - immunosuppressive activity - cytotoxic activity

References

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