Planta Med 2010; 76(16): 1907-1910
DOI: 10.1055/s-0030-1249979
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Activity of Trijugin-Type Limonoids from Cipadessa baccifera

Jing Ning1 , 2 , Ying-Tong Di1 , Yuan-Yuan Wang1 , Hong-Ping He1 , Xin Fang1 , Yan Li1 , Shun-Lin Li1 , Xiao-Jiang Hao1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
  • 2Graduate School of Chinese Academy of Sciences, Beijing, P. R. China
Further Information

Publication History

received March 7, 2010 revised April 13, 2010

accepted April 26, 2010

Publication Date:
27 May 2010 (online)

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Abstract

Two new trijugin-type limonoids, cipatrijugins E and F (1 and 2), together with the known cipatrijugins A and D (34), were isolated from the stem bark of Cipadessa baccifera. All structures were elucidated by spectroscopic analysis. The in vitro cytotoxicity of compounds 14 was also tested. Compound 1 showed significant in vitro cytotoxicity against MCF-7, SW480, HL-60, and SMMC-7721 cells, with IC50 values of 5.0, 6.6, 4.5, and 21.6 µM, respectively.

References

Prof. Dr. Xiao-Jiang Hao

Kunming Institute of Botany
Chinese Academy of Sciences

134 lanhei Road

650204 Kunming

People's Republic of China

Phone: + 86 87 15 22 32 63

Fax: + 86 87 15 22 30 70

Email: haoxj@mail.kib.ac.cn