Planta Med 2011; 77(3): 281-283
DOI: 10.1055/s-0030-1250333
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

A Novel Taxane 13-Glucoside and Other Taxanes from the Leaves of Taxus cuspidata

Zhi-Yu Ni1 , 2 , Mei Dong1 , 2 , Bin Cong2 , Françoise Sauriol3 , Man-Li Zhang1 , Yu-Fang Wang1 , Chang-Hong Huo1 , Qing-Wen Shi1 , Hiromasa Kiyota4
  • 1Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Hebei, P. R. China
  • 2College of Basic Medicine, Hebei Medical University, Hebei, P. R. China
  • 3Department of Chemistry, Queen's University, Kingston, Ontario, Canada
  • 4Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
Further Information

Publication History

received June 11, 2010 revised July 9, 2010

accepted August 14, 2010

Publication Date:
22 September 2010 (online)

Abstract

Three new taxanes, 2α,9α,10β-triacetoxy-13α-(β-D-glucopyranosyloxy)taxa-4(20),11-dien-5α-ol (1), 5α,10β,13α-triacetoxytax-11-ene-2α,7β,9α,20-tetraol (2), and 5α,10β,13β-triacetoxy-2α,7β-dihydroxy-2(3 → 20)abeotaxa-4(20),11-dien-9-one (3), were isolated from the leaves of the Japanese yew, Taxus cuspidata. Compound 1 is the first example of a taxane with 13-glycosidic linkage.

References

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Prof. Qing-Wen Shi

Department of Medicinal Natural Product Chemistry
School of Pharmaceutical Sciences
Hebei Medical University

361 Zhongshan East Road

050017 Shijiazhuang

Hebei Province

People's Republic of China

Phone: +86 3 11 86 26 56 34

Fax: +86 3 11 86 26 56 34

Email: qingwen@hebmu.edu.cn

Associate Prof. Hiromasa Kiyota

Graduate School of Agricultural Science
Tohoku University

Sendai, Miyagi

981-8555

Japan

Phone: +81 22 7 17 87 85

Fax: +81 22 7 17 87 85

Email: kiyota@biochem.tohoku.ac.jp