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Planta Med 2011; 77(5): 441-449
DOI: 10.1055/s-0030-1250458
Biological and Pharmacological Activity
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Epifriedelanol from the Root Bark of Ulmus davidiana Inhibits Cellular Senescence in Human Primary Cells

Hyo Hyun Yang1 [*] , Jong-Keun Son2 [*] , Bochan Jung3 [*] , MingShan Zheng2 , 4 , Jae-Ryong Kim1
  • 1Department of Biochemistry and Molecular Biology, Aging-associated Vascular Disease Research Center, College of Medicine, Yeungnam University, Daegu, Republic of Korea
  • 2College of Pharmacy, Yeungnam University, Gyongsan, Republic of Korea
  • 3Department of Laboratory Medicine, CHA Gumi Medical Center, CHA University, Gyeongsangbuk-do, Republic of Korea
  • 4College of Pharmacy, Yanbian University, Yanji, P. R. China
Further Information

Publication History

received July 28, 2010 revised –

accepted Sept. 28, 2010

Publication Date:
03 November 2010 (online)

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Abstract

Since cellular senescence involves organismal aging as well as diverse diseases, aging intervention might contribute to inhibit the aging process as well as aging-associated diseases. We tried to search for effective compounds from the root bark of Ulmus davidiana that are able to inhibit cellular senescence in human fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs). Twenty-two compounds from the root bark of U. davidiana were isolated and screened for their inhibitory effects on adriamycin-induced cellular senescence by measuring senescence-associated β-galatosidase (SA-β-gal) activity. Among twenty-two compounds isolated, epifriedelanol (3), ssioriside (15), and catechin-7-O-β-D-glucopyranoside (22) had inhibitory effects on adriamycin-induced cellular senescence in HDFs. Friedelin (2), epifriedelanol (3), and catechin-7-O-β-apiofuranoside (18) were active in HUVECs. In particular, epifriedelanol (3) suppressed adriamycin-induced cellular senescence as well as replicative senescence in HDFs and HUVECs. These results suggest that epifriedelanol (3) reduces cellular senescence in human primary cells and might be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases.

Key words

Ulmus davidiana var. japonica - Ulmaceae - cellular senescence - epifriedelanol - human primary cells - aging intervention

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1 These authors contributed equally to this work.

Prof. Dr. Jae-Ryong Kim

Department of Biochemistry and Molecular Biology
College of Medicine, Yeungnam University

317-1 Daemyung-Dong

Daegu 705-717

Republic of Korea

Phone: +82 5 36 20 43 42

Fax: +82 5 36 54 66 51

Email: kimjr@ynu.ac.kr

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