Download PDF
Synfacts 2010(8): 0856-0856  
DOI: 10.1055/s-0030-1257742
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of MK-5596

Contributor(s): Philip Kocienski
L. Yan et al.*
Merck Research Laboratories, Rahway, USA
Further Information

Publication History

Publication Date:
22 July 2010 (online)

    Permissions and Reprints

Significance

The cannabinoid-1 receptor (CB1R) is a G-protein coupled receptor, widely expressed in the CNS and peripheral tissues, that plays an important role in regulating energy balance. MK-5596 is a CB1R inverse agonist that reduces body weight and food intake in obese rats and hence is being developed for the treatment of obesity.