Download PDF
Synfacts 2010(9): 1057-1057  
DOI: 10.1055/s-0030-1257896
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Cross-Coupling by Intramolecular Activation of Trialkylsilanes

Contributor(s): Paul Knochel, Andreas J. Wagner
Y. Nakao*, M. Takeda, T. Matsumoto, T. Hiyama*
Kyoto University, Japan
Further Information

Publication History

Publication Date:
23 August 2010 (online)

    Permissions and Reprints

Significance

Herein, the authors report that 2-(2-hydroxyprop-2-yl)phenyl-substituted alkyl­silanes selectively transfer an alkyl group to aryl and heteroaryl chlorides and bromides under palladium catalysis. Primary and secondary alkyl chains can be cross-coupled affording the alkylated products in very good yields.