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Synfacts 2010(9): 0986-0986  
DOI: 10.1055/s-0030-1257931
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (±)-Strychnine and (±)-Akuammicine

Contributor(s): Steven V. Ley, Philippa B. Cranwell
G. Sirasani, T. Paul, W. Dougherty Jr., S. Kassel, R. B. Andrade*
Temple University Philadelphia and Villanova University, USA
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

Indole alkaloids akuammicine and strychnine are members of the Strychnos family. Their complex molecular structure has made them a popular target for synthesis since 1954, when the first total synthesis of strychnine was disclosed by Woodward (J. Am. Chem. Soc. 1954, 76, 4749).