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Synfacts 2010(9): 1073-1073  
DOI: 10.1055/s-0030-1257970
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Organo- and Gold-Catalyzed One-Pot Synthesis of Dihydropyrroles

Contributor(s): Benjamin List, Anna Lee
D. Monge, K. L. Jensen, P. T. Franke, L. Lykke, K. A. Jørgensen*
Aarhus University, Denmark
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

An efficient organo- and gold-­catalyzed one-pot synthesis of chiral dihydropyrrole derivatives is reported by Jørgensen and co-workers. The desired products were obtained in good yields and high enantioselectivities through a bifunctional organocatalytic Mannich-type reaction and a gold-catalyzed alkyne hydroamination and isomerization.