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Synfacts 2010(9): 1035-1035
DOI: 10.1055/s-0030-1257991
DOI: 10.1055/s-0030-1257991
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Construction of (E)-δ-Stannyl Homoallylic Alcohols
M. Chen, D. H. Ess, W. R. Roush*
Scripps Florida, Jupiter, USA
Further Information
Publication History
Publication Date:
23 August 2010 (online)
Significance
The hydroboration of aldehydes with allylborane reagents usually gives homoallylic alcohols with terminal vinyl and β-substituents. In this work, the authors envisioned the β-carbocation-stabilizing effect of trialkyltin and succeeded the synthesis of (E)-δ-stannyl homoallylic alcohols in high stereoselectivities. These compounds could be very useful chiral synthetic building blocks upon further functionalization.