Nicotinamide plays a key role in many biological processes and,
as a consequence, its derivatives could be attractive for the synthesis
of biologically active compounds. Here a rapid and efficient way
of preparing alkyl derivatives of nicotinamide, precisely, 4-alkyl-3-carbamoylpyridine
and 4-alkyl-3,5-dicarbamoylpyridine is reported. The synthetic route
developed adopts mild reaction conditions and produces target compounds
in higher yields compared with methods described in literature.
amides - drugs - hydrogenation - nicotinamide
derivatives - nitrile hydrolysis - pyridines
