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Synthesis 2011(1): 73-78
DOI: 10.1055/s-0030-1258332
DOI: 10.1055/s-0030-1258332
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkAn Eco-Sustainable Erbium(III) Triflate Catalyzed Formation and Cleavage of tert-Butyl Ethers
Further Information
Received
13 September 2010
Publication Date:
15 November 2010 (online)
Publication History
Publication Date:
15 November 2010 (online)
Abstract
An eco-compatible method, which permits the formation or cleavage of tert-butyl ethers of alcohols and phenols, is proposed. The protection step is performed in solvent-free conditions at room temperature using catalytic amount of Er(OTf)3. The catalyst is easily recovered from the aqueous phase and reused several times without significant loss of activity. The deprotection step developed is also highly eco-friendly since the tert-butyl group is removed very quickly from alcohols and phenols in methanol using MW irradiation.
Key words
green chemistry - Lewis acid - protecting groups - tert-butyl ether - microwave heating
- Supporting Information for this article is available online:
- Supporting Information
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