Convenient Synthesis of a Library of Lactam-Fused β-Carbolines via the Ugi Reaction [¹]

Abstract

We present a convenient synthesis of a chemical library of lactam-fused β-carbolines via a Ugi four-center three-component reaction employing [1-formyl-3-(methoxycarbonyl)-9H-pyrido[3,4-b]indol-9-yl]acetic acid or (1-formyl-9H-pyrido[3,4-b]indol-9-yl)acetic acid, amines and isonitriles.

Ugi reaction - multicomponent reactions - β-carbolines

References

<A NAME="RP16410SS-1">1</A>

CDRI Communication No. 7998.

<A NAME="RP16410SS-2">2</A>

Graduate Trainee from the National Institute of Pharmaceutical Education and Research, Raebareli, India.

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