Synthesis 2011(6): 984-992  
DOI: 10.1055/s-0030-1258446
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of New Dihydropyrimido[4,5-b]quinolinetrione Derivatives Using a Four-Component Coupling Reaction

A. Khalafi-Nezhad*, F. Panahi*
Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
Fax: +98(711)2280926; e-Mail: khalafi@chem.susc.ac.ir;
Further Information

Publication History

Received 1 December 2010
Publication Date:
24 February 2011 (online)

Abstract

A convenient and one-pot method for the efficient synthesis of the novel 8,9-dihydro-8,8-dimethyl-5,10-diphenylpyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)-trione derivatives via a four-component condensation reaction of aldehydes, amines, dimedone, and barbituric acid in the presence of tungestophosphoric acid (H3PW12O40) as catalyst is described. This new approach proceeded smoothly in good to excellent yields and the pure products are separated from the reaction mixture by simple filtration.

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