Palladium-Catalyzed Regioselective Arylation of Indoles with
Arylsiloxanes

doi:10.1055/s-0030-1258594

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Synfacts 2010(10): 1178-1178
DOI: 10.1055/s-0030-1258594

Metal-Mediated Synthesis

Palladium-Catalyzed Regioselective Arylation of Indoles with Arylsiloxanes

Contributor(s): Paul Knochel, Andreas J. Wagner
Z. Liang, B. Yao, Y. Zhang*
Zhejiang University, Hangzhou, P. R. of China

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Publication History

Publication Date:
22 September 2010 (online)

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Significance

A mild Pd(OAc)₂-catalyzed cross-coupling of indoles and substituted aryl siloxanes has been developed. Key reagents are Ag₂O as an oxidant and TBAF as desilylating agent. Various substituted indoles afford the 2-arylated products in satisfactory to very good yields.