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Synfacts 2010(11): 1288-1288  
DOI: 10.1055/s-0030-1258719
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Iron-Catalyzed Addition of Acid Chlorides to Alkynes

Contributor(s): Paul Knochel, Thomas Kunz
B. Wang, S. Wang, P. Li, L. Wang*
Huaibei Normal University, P. R. of China
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Publikationsdatum:
21. Oktober 2010 (online)

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Significance

An atom-economical approach to β-chloro-α,β-unsaturated ketones is described. The iron(II) bromide catalyzed addition of acid chlorides to alkynes shows excellent regio- and stereoselectivity (Z/E > 99:1), but only a moderate tolerance towards functionalities has been reported.