Cobalt-Catalyzed Hydroarylation of Alkynes Through C-H
Bond Activation

doi:10.1055/s-0030-1258858

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Synfacts 2010(12): 1410-1410
DOI: 10.1055/s-0030-1258858

Metal-Mediated Synthesis

Cobalt-Catalyzed Hydroarylation of Alkynes Through C-H Bond Activation

Contributor(s): Paul Knochel, Andreas J. Wagner
K. Gao, P.-S. Lee, T. Fujita, N. Yoshikai*
Nanyang Technological University, Singapore

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Publication History

Publication Date:
22 November 2010 (online)

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Significance

A ternary catalytic system consisting of CoBr₂, PMePh₂, and MeMgCl has been developed. It promotes efficiently the addition of a variety of biaryl heteroaromatics to unactivated internal alkynes with high regioselectivities.