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Synfacts 2010(12): 1378-1378  
DOI: 10.1055/s-0030-1258890
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

New Chiral Bidentate Secondary Phosphine Oxide Ligands for Hydrogenation

Contributor(s): Mark Lautens, Stephen G. Newman
H. Landert, F. Spindler, A. Wyss, H.-U. Blaser, B. Pugin*, Y. Ribourduoille, B. Gschwend, B. Ramalingam, A. Pfaltz*
Solvias AG, Basel and University of Basel, Switzerland
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Publikationsdatum:
22. November 2010 (online)

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Significance

Bidentate phosphine ligands are exceptionally useful for enantioselective catalysis. The use of chiral secondary phosphine oxides (SPOs) is a much less well-developed field. The authors explore the use of mixed ligands containing both an SPO and a phosphine moiety. The ­resulting ligands - named JoSPOphos for those with a Josiphos-like backbond, and TerSPOphos for those based on chiral terpenes - demonstrate high activity and enantioselectivity in asymmetric hydrogenations of alkenes.