Copper-Catalyzed Intermolecular Oxidative [3+2] Cycloaddition

doi:10.1055/s-0030-1259425

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Synfacts 2011(3): 0318-0318
DOI: 10.1055/s-0030-1259425

Metal-Mediated Synthesis

Copper-Catalyzed Intermolecular Oxidative [3+2] Cycloaddition

Contributor(s): Paul Knochel, Thomas Kunz
L. Huang, H. Jiang*, C. Qi, X. Liu
South China University of Technology, Guangzhou, P. R. of China

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Publication History

Publication Date:
16 February 2011 (online)

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Significance

A new synthetic approach to γ-lactones via an intermolecular oxidative [3+2] cycloaddition of alkenes with anhydrides is reported. This copper(II)-catalyzed cyclization uses oxygen as sole oxidant and the anhydride as solvent and proceeds well for a broad range of substrates.