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Synthesis 2011(10): 1599-1603  
DOI: 10.1055/s-0030-1259992
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Facile and Efficient Synthesis of 2-Imidazolines from Aldehydes Using Hydrogen Peroxide and Substoichiometric Sodium Iodide

Guo-yi Bai*, Kai Xu, Guo-feng Chen, Yong-hui Yang, Tian-yu Li
Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. of China
Fax: +86(312)5937102; e-Mail: gybai@hbu.edu.cn;
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Publication History

Received 26 January 2011
Publication Date:
05 April 2011 (online)

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Abstract

The reaction of aldehydes with ethylenediamine for the preparation of 2-imidazolines has been studied using hydrogen peroxide as an oxidant in the presence of sodium iodide and anhydrous magnesium sulfate. A mild, green, and efficient method is established to carry out this reaction in high yield.

Key words

2-imidazoline - hydrogen peroxide - aldehydes - ethylenediamine - environmentally friendly process

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