One-Pot Synthesis of Fused-Tetracyclic Scaffolds Employing a Lewis Acid Promoted Domino Reaction of Naphthoquinones

Abstract

The facile synthesis of tetracyclic molecular frameworks employing a Lewis acid promoted domino reaction of naphthoquinones with hydroxy- and amino-functionalized cross-conjugated trienes is reported. The reaction cascade involves a heterocyclization via hemiacetal or imine formation, and an intramolecular Diels­-Alder cycloaddition.

tetracyclic scaffolds - naphthoquinone - Lewis acid promoted domino reaction - intramolecular Diels-Alder cycloaddition

References

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