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Synthesis 2011(17): 2781-2788
DOI: 10.1055/s-0030-1260132
DOI: 10.1055/s-0030-1260132
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkN-Bromosuccinimide-Promoted Cyclization of β-Carboxymethyl Enamino Esters; Synthesis of Functionalized 4-Amino-2(5H)-Furanones
Further Information
Received
6 April 2011
Publication Date:
21 July 2011 (online)
Publication History
Publication Date:
21 July 2011 (online)
Abstract
An easy, two-step approach to various 5-carboxymethyl-2(5H)-furanones is described. A detailed study of the reaction of β-carboxymethyl enamino esters with N-bromosuccinimide is presented.
Key words
tetronamides - 4-amino-2(5H)-furanones - bromocyclization - alkylation - decarborxylation
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Data were obtained from reactions with less than 5% deviation