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DOI: 10.1055/s-0030-1260156
Synthesis of 1,2-Diketones from β-Keto Nitriles via a Protection-Oxidative-Decyanation-Deprotection Protocol
Publication History
Publication Date:
05 August 2011 (online)

Abstract
A variety of 1,2-diketones were prepared from β-keto nitriles via a three-step protocol including the protection of the ketones with methoxyamine, oxidative decyanation, and microwave-assisted deprotection in the final step. This approach provides a novel and efficient access to a wide scope of symmetric and unsymmetric 1,2-diketones using molecular oxygen as the oxidant in the decyanation process.
Key words
β-keto nitriles - oxygen - oxidative decyanation - microwave - 1,2-diketones
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- Supporting Information
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