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Synfacts 2011(7): 0731-0731  
DOI: 10.1055/s-0030-1260614
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Intramolecular Coupling of Arenes via Friedel-Crafts Reaction of Fluoroarenes

Contributor(s): Timothy M. Swager, Jason R. Cox
O. Allemann, S. Duttwyler, P. Romanato, K. K. Baldridge, J. S. Siegel*
University of Zürich, Switzerland
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

Silyl cations, driven by the formation of strong Si-F bonds, are used to activate ­fluoroarenes in intramolecular Friedel-Crafts reactions. This new methodology provides polycyclic aromatic hydrocarbons in good to excellent yields.