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Synfacts 2011(8): 0886-0886  
DOI: 10.1055/s-0030-1260726
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Cyanomethylation of Aryl Halides

Contributor(s): Paul Knochel, Thomas Kunz
J. Velcicky*, A. Soicke, R. Steiner, H.-G. Schmalz*
Novartis Institutes for Biomedical Research, Basel, Switzerland and University of Cologne, Germany
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Publikationsverlauf

Publikationsdatum:
20. Juli 2011 (online)

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Significance

Herein, an efficient and general protocol for the cyanomethylation of aryl halides and triflates is disclosed. A wide range of electron-donating or electron-accepting functional groups is tolerated on the aryl halide and the desired products are obtained in good yields.