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Synfacts 2011(8): 0873-0873  
DOI: 10.1055/s-0030-1260833
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

New Ligand for Zinc-Catalyzed Hydroxylation of β-Keto Esters and 1,3-Diesters

Contributor(s): Mark Lautens, Jane Panteleev
J. Li, G. Chen, Z. Wang, R. Zhang, X. Zhang, K. Ding*
Shanghai Institute of Organic Chemistry, P. R. of China and The State University of New Jersey, Piscataway, USA
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Publication History

Publication Date:
20 July 2011 (online)

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Significance

Asymmetric hydroxylation of β-keto esters and 1,3-diesters is one of the most popular approaches to access α-hydroxy-β-keto esters such as 2. This work describes the development and application of a new spirocyclic ligand in a zinc-catalyzed enantioselective hydroxylation to access 2. This work presents a superior system since the reaction times are short and catalyst loading could be decreased to 0.1 mol%.