A Practical Synthesis of Alendronate Sodium through Counterattack Reaction

Abstract

An efficient synthesis of alendronate sodium, an osteoporosis drug, has been developed through ‘counterattack reaction’ involving treatment of the respective acyl phosphonate with (MeO)₃P and TMSBr followed by deblocking with aqueous HCl.

Key words

drugs - green chemistry - nucleophilic addition - elimination - phosphorus - protecting groups

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