Convenient One-Pot Two-Step Synthesis of 1,3-Thiazoles via Organocatalyzed Epoxidation of Nitroolefins

Shengwei Wei; Katharina M. Weiß; Svetlana B. Tsogoeva

doi:10.1055/s-0031-1291139

Synthesis, Inhaltsverzeichnis

Synthesis 2012; 44(22): 3441-3446
DOI: 10.1055/s-0031-1291139

practical synthetic procedures

Convenient One-Pot Two-Step Synthesis of 1,3-Thiazoles via Organocatalyzed Epoxidation of Nitroolefins

Shengwei Wei

Department of Chemistry and Pharmacy, Institute of Organic Chemistry 1, University of Erlangen-Nuremberg, Henkestraße 42, 91054 Erlangen, Germany, Fax: +49(9131)8526865 eMail: tsogoeva@chemie.uni-erlangen.de

,

Katharina M. Weiß

Department of Chemistry and Pharmacy, Institute of Organic Chemistry 1, University of Erlangen-Nuremberg, Henkestraße 42, 91054 Erlangen, Germany, Fax: +49(9131)8526865 eMail: tsogoeva@chemie.uni-erlangen.de

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Svetlana B. Tsogoeva*

Department of Chemistry and Pharmacy, Institute of Organic Chemistry 1, University of Erlangen-Nuremberg, Henkestraße 42, 91054 Erlangen, Germany, Fax: +49(9131)8526865 eMail: tsogoeva@chemie.uni-erlangen.de

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Abstract

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Abstract

A convenient novel one-pot two-step strategy and its substrate scope for the synthesis of 1,3-thiazole heterocycles via organocatalytic epoxidation of nitroolefins with the TBHP/DBU system, and subsequent reaction of α-nitroepoxides with thioamides is reported.

Key words

thiazole - epoxidation - DBU - one-pot reaction - organocatalysis

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Referenzen

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