Cytotoxic Triterpenoid Saponins from Ardisia gigantifolia

Abstract

Three new triterpenoid saponins, 1–3, together with two known saponins, 4 and 5, were isolated from the rhizome of Ardisia gigantifolia. Their structures were elucidated by 1D and 2D NMR spectroscopic studies. Saponins 1, 2, 4, and 5 exhibited significant cytotoxicity against four human cancer cell lines, namely, Hela human cervical carcinoma cells, EJ human bladder tumor cells, HepG-2 human hepatoma cells, and BCG human gastric carcinoma cells with IC₅₀ values in the range of 1.9–4.8 µM.

Ardisia gigantifolia - Myrsinaceae - triterpenoid saponin - cytotoxic activity

References

• 1 Mu L H, Gong Q Q, Zhao H X, Liu P. Triterpenoid saponins from Ardisia gigantifolia.  Chem Pharm Bull. 2010;  58 1248-1251
• 2 Yokosuka A, Sano T, Hashimoto K, Sakagami H, Mimaki Y. Triterpene glycosides from the whole plant of Anemone hupehensis var. japonica and their cytotoxic activity.  Chem Pharm Bull. 2009;  57 1425-1430
• 3 Li W, Bi X Y, Wang K, Li D X, Satou T, Koike K. Triterpenoid saponins from Impatiens siculifer.  Phytochemistry. 2009;  70 816-821
• 4 Feather M S, Harris J F. Dehydration reaction of carbohydrates.  Adv Carbohydr Chem Biochem. 1973;  28 161-237
• 5 Chang X L, Wei L, Jia Z H, Statou T, Fushiya S, Koke K. Biologically active triterpenoid saponins from Ardisia japonica.  J Nat Prod. 2007;  70 179-187
• 6 Luo J G, Ma L, Kong L Y. New triterpenoid saponins with strong a-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana.  Bioorg Med Chem. 2008;  16 2912-2920
• 7 Wen P, Zhang X M, Yang Z, Wang N L, Yao X S. Four new triterpenoid saponins from Ardisia gigantifolia Stapf. and their cytotoxic activity.  J Asian Nat Prod Res. 2008;  10 873-880

1 These authors contributed equally to this work.